Gene Synthesis Market Size, Share Global Analysis Report, 2022 – 2028

Industry Insights

[215+ Pages Report] According to Facts and Factors, the global gene synthesis market size was worth around USD 1,528.10 million in 2021 and is estimated to grow to about USD 4,021.41 million by 2028, with a compound annual growth rate (CAGR) of approximately 17.50% over the forecast period. The report analyzes the gene synthesis market's drivers, restraints/challenges, and their effect on the demands during the projection period. In addition, the report explores emerging opportunities in the gene synthesis market.

Market Overview

Gene synthesis is the process of creating artificial genes using rational scientific methods. Additionally, "gene synthesis" describes how genes are created using various techniques designed to assemble and synthesize genes from nucleotides. A nucleotide is a fundamental building block used to make nucleic acid. In synthetic biology, the top-down approach and bottom-up approach are primarily employed. Redesigning and creating new biological systems to produce manufactured goods is a top-down strategy.

A bottom-up process entails inventing and creating biological systems or gadgets from scratch that do not already exist in nature. The synthetic biology business's creation results from the urgent need to comprehend how genetic components, cells, and biological processes work. The pharmaceutical, diagnostic, energy, bioplastics, and environmental sectors employ the products created in this novel physical system.

COVID-19 Impact:

Following the pandemic, the market for gene synthesis in healthcare is anticipated to expand significantly. Due to lockdowns, travel restrictions, and company closures, COVID-19 has impacted the economy and sectors of many different nations. The COVID-19 issue has overburdened public health systems in several countries and highlighted the urgent requirement for long-term investments in healthcare infrastructure. As the COVID-19 pandemic spreads, the healthcare sector's growth is projected to stall. However, the medical technology and imaging industry is seeing a fall in revenues due to fewer surgeries being carried out and postponed or delayed equipment purchases.

Key Insights

• As per the analysis shared by our research analyst, the global gene synthesis market will grow at a CAGR of 17.50% over the forecast period.
• In terms of revenue, the global gene synthesis market size was valued at around USD 1528.10 million in 2021 and is projected to reach USD 4021.41 million by 2028.
• The primary factor propelling the market is the rise in synthetic biology research labs. The primary reason for the increase in synthetic biology research labs is the development of new research and development techniques in the biotech and pharmaceutical sectors. The research, development, and marketing of pharmaceuticals used in treatments given to patients to prevent and cure their ailments are referred to as activities in the pharmaceutical business.
• By Method, the solid-phase synthesis category dominated the market in 2021.
• By Application, the gene & cell therapy development category dominated the market in 2021.
• North America dominated the global smart hospitals market in 2021.

Growth Drivers

• More focus is being placed on clinical research to uncover biological systems at their most basic molecular level to drive market growth.

It is projected that over the next few years, demand in the gene synthesis market will be driven by a greater emphasis on clinical research to uncover biological systems at the fundamental molecular level. The growth of life science research results from recent technical developments that have produced well-designed goods and services, including molecular separation, gene synthesis on microchips, and protein purification. Gene synthesis has been recognized as an effective and affordable substitute for conventional cloning and mutagenesis processes. Federal funding for several university research initiatives is being pushed for by these trustworthy and time-saving solutions in industrialized nations and is also driving the market. However, it is projected that variables like intense competition that would result in a price decrease and technological restrictions throughout the production process will make the gene less effective.

Restraints

• Lack of qualified personnel to limit market growth

One of the main challenges holding back the worldwide gene synthesis market is the industry's shortage of expertise. Another problem projected to reduce the market value of gene synthesis in the coming years is the abuse of gene synthesis, which refers to the exploitation of gene information for reasons other than forensic research.

Opportunity

• The growing number of people with genetic and chronic diseases will generate massive investment opportunities.

Due to the growing need for gene synthesis among the worldwide population suffering from hereditary and chronic illnesses, the market for gene synthesis is expanding extremely quickly. Additionally, a study published by Science Direct in 2018 found that chronic diseases are one of the most significant issues in industrialized nations and account for 80% of mortality in middle-income countries with an aging population. These diseases include cancer. One of the factors that will favorably impact the gene synthesis industry is the rising public desire for targeted and customized therapy.

Segmentation Analysis

The global gene synthesis market is segregated based on Method, Service, Application, end-user, and region.

Due to the most significant adoption rate over the previous few years, the solid-phase synthesis sector accounted for the largest revenue share. The incredible accuracy of this approach also encourages its use in research settings and among therapy makers. However, its high expense and poor productivity make it less useful in other situations, opening doors for alternative techniques. Over the projected period, considerable CAGRs are expected to be registered by PCR- and chip-based approaches. These processes enable the synthesis of more significant pieces at a slower rate, which has led to a rise in their use.

The development of gene and cell therapies made for the most significant revenue share. The pipeline of cutting-edge medicines for chronic illnesses is expected to keep growing. Due to their superior effectiveness in treating conditions that cannot be treated using the traditional manner of disease treatment, these treatments rapidly grow in favor among therapy developers. New cures are being actively developed by businesses and academic organizations worldwide, which will probably increase the demand for services in this industry. The companies also fund fundraising and investments to improve their regenerative medicine and stem cell treatment capacity.

The antibody DNA synthesis sector dominated the market with the most significant revenue share. The dominance of this market sector is due to the large number of market participants that provide services for antibody DNA synthesis. To enable the cloning and manufacturing of antibody heavy/light chain sequences into any bespoke vector, businesses are providing their services to pharmaceutical/biotech firms and academic research centers. On the other hand, due to the rising virus vector-related spending, the viral gene synthesis category is anticipated to record the quickest CAGR from 2021 to 2028.

Based on End-user, the market is segmented into research organizations, academic and research institutes, biopharmaceutical businesses, the gene synthesis. The academic and research institutions segment dominated the market for gene synthesis. For the improvement of gene synthesis, several organizations support educational and research institutions. In addition, several organizations have emerged due to collaborations between various institutions and organizations for research into applying scientific technology to developing patient-saving therapies.

Report Scope

Recent Developments

• September 2021:Cyrus Biotechnology and Selecta Biosciences have partnered to create Therapeutic Proteins. Innovative breakthroughs in therapeutic research will be facilitated by novel interleukin-2 (IL-2) technologies.
• November 2020: The Synthetic Biology Innovation Accelerator will begin operations thanks to a partnership between Codexis and Casdin Capital. In the biotech sector, it will be beneficial to establish distinctive product capabilities.

Regional Landscape

• The most considerable CAGR is anticipated for the North American area, primarily due to the faster development of contemporary biotechnology and protein crystallization processes.

Due to significant businesses and encouraging government activities on developing and implementing synthetic biology projects, North America accounted for the most critical revenue share. The growth of the regional market is facilitated by the increasing use of gene editing and synthesis-related techniques by medication and diagnostic companies in the U.S. The commercialization of synthetic gene products and regulatory approval of those items in the area have also contributed to the market expansion.

The recent approval of many cellular and gene therapies in the area encourages other businesses to invest in this field. The fastest CAGR is anticipated to occur in the Asia Pacific between 2022 and 2028. This is due to increased investments by multinational corporations in the local market. Additionally, the expansion of the industry is aided by the presence of several essential corporations in developing countries like China and India.

Competitive Landscape

Key players within the global Gene Synthesis market include 

• GenScript 
• GENEWIZ 
• Boster Biological Technology 
• Twist Bioscience 
• ProteoGenix 
• Biomatik 
• ProMab Biotechnologies Inc. 
• Thermo Fisher Scientific Inc. 
• Integrated DNA Technologies Inc. 
• OriGene Technologies Inc.

The global gene synthesis market is segmented as follows:

By Method

• Solid-phase Synthesis
• Chip-based Synthesis
• PCR-based Enzyme Synthesis

By Service

• Antibody DNA Synthesis
• Viral DNA Synthesis
• Others

By Application

• Gene & Cell Therapy Development
• Vaccine Development
• Disease Diagnosis
• Others

By End User

• Biotechnology & Pharmaceutical Companies
• Academic & Government Research Institutes
• Contract Research Organizations

By Region

• North America
  • The U.S.
  • Canada
  • Mexico
• Europe
  • France
  • The UK
  • Spain
  • Germany
  • Italy
  • Nordic Countries
    • Denmark
    • Sweden
    • Norway
  • Benelux Union
    • Belgium
    • The Netherlands
    • Luxembourg
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • Australia
  • South Korea
  • Southeast Asia
    • Indonesia
    • Thailand
    • Malaysia
    • Singapore
    • Rest of Southeast Asia
  • Rest of Asia Pacific
• The Middle East & Africa
  • Saudi Arabia
  • UAE
  • Egypt
  • South Africa
  • Rest of the Middle East & Africa
• Latin America
  • Brazil
  • Argentina
  • Rest of Latin America